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It should be noted, however, that symptomatic vitamin E deficiency in healthy individuals who consume diets low in vitamin E has never been reported (58, 59)

Song Q, Feng YB, Wang L, Shen J, Li Y, Fan C, et al

Various pathways, including pentose phosphate pathway (PPP) 21,22,23,24 , malic enzyme 25,26 , isocitrate dehydrogenase 27,28 and folate pathways 29,30 , have been reported to contribute significantly under different situations (for example, biosynthesis during proliferation, lipogenesis, redox defence and so on)

Simultaneous Visualization of Multiple Protein Interactions in Living Cells Using Multicolor Fluorescence Complementation Analysis

Cell 161 , 486500 (2015)

The accuracy of predicting the cleavage points of known mammalian secretory proteins for each of these methods is in the range of 75-80%